| Wednesday, 23 Feb 2011 |
| HOME TEAM | | TIME | | AWAY TEAM |
| CSKA Moskva | | 00:00 | | PAOK |
| Thursday, 24 Feb 2011 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Porto | | 00:00 | | Sevilla |
| Friday, 25 Feb 2011 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Bayer Leverkusen | | 01:00 | | Metalist |
| Sporting Lisbon | | 01:00 | | Rangers |
| Liverpool | | 01:00 | | Sparta Praha |
| Spartak Moskva | | 01:00 | | Basel |
| Zenit | | 01:00 | | Young Boys |
| PSV | | 01:00 | | Lille |
| Manchester City | | 03:05 | | Aris |
| Twente | | 03:05 | | Rubin Kazan |
| Villarreal | | 03:05 | | Napoli |
| Ajax | | 03:05 | | Anderlecht |
| Sporting Braga | | 03:05 | | Lech Poznan |
| Dynamo Kyiv | | 03:05 | | Besiktas |
| Stuttgart | | 03:05 | | Benfica |
| PSG | | 03:05 | | BATE |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
