| Wednesday, 8 Dec 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Twente | | 02:45 | | Tottenham Hotspur |
| Werder Bremen | | 02:45 | | Internazionale |
| Olympique Lyon | | 02:45 | | Hapoel Tel Aviv |
| Benfica | | 02:45 | | Schalke 04 |
| Manchester United | | 02:45 | | Valencia |
| Barcelona | | 02:45 | | Rubin Kazan |
| København | | 02:45 | | Panathinaikos |
| Bursaspor | | 02:45 | | Rangers |
| Thursday, 9 Dec 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Bayern München | | 02:45 | | Basel |
| CFR Cluj | | 02:45 | | Roma |
| Olympique Marseille | | 02:45 | | Chelsea |
| Žilina | | 02:45 | | Spartak Moskva |
| Milan | | 02:45 | | Ajax |
| Real Madrid | | 02:45 | | Auxerre |
| Shakhtar Donetsk | | 02:45 | | Sporting Braga |
| Arsenal | | 02:45 | | Partizan |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
