| Saturday, 11 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Barcelona | | 23:00 | | Hércules |
| Valencia | | 23:00 | | Racing Santander |
| Sunday, 12 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Real Madrid | | 01:00 | | Osasuna |
| Athletic Bilbao | | 03:00 | | Atlético Madrid |
| Sporting Gijón | | 22:00 | | Mallorca |
| Real Zaragoza | | 22:00 | | Málaga |
| Getafe | | 22:00 | | Levante |
| Monday, 13 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Villarreal | | 00:00 | | Espanyol |
| Sevilla | | 02:00 | | Deportivo La Coruña |
| Tuesday, 14 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Almería | | 02:00 | | Real Sociedad |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
