| Thursday, 2 Dec 2010 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Sampdoria | | 1 - 2 | | PSV |
| Metalist | | 2 - 1 | | Debrecen |
| OB | | 1 - 1 | | Getafe |
| Hajduk Split | | 1 - 3 | | AEK |
| Zenit St. Petersburg | | 3 - 1 | | Anderlecht |
| Young Boys | | 4 - 2 | | Stuttgart |
| Gent | | 1 - 0 | | Levski Sofia |
| Sporting Lisbon | | 1 - 0 | | Lille |
| Rosenborg | | 0 - 1 | | Bayer Leverkusen |
| Atlético Madrid | | 2 - 3 | | Aris |
| Lech Poznan | | 1 - 1 | | Juventus |
| Manchester City | | 3 - 0 | | Salzburg |
| Friday, 3 Dec 2010 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| CSKA Sofia | | 1 - 2 | | Besiktas |
| Utrecht | | 3 - 3 | | Napoli |
| Rapid Wien | | 1 - 3 | | Porto |
| Steaua Bucureşti | | 1 - 1 | | Liverpool |
| PSG | | 4 - 2 | | Sevilla |
| Borussia Dortmund | | 3 - 0 | | Karpaty |
| CSKA Moskva | | 5 - 1 | | Lausanne Sports |
| Palermo | | 2 - 2 | | Sparta Praha |
| BATE | | 1 - 4 | | Dynamo Kyiv |
| Sheriff | | 1 - 1 | | AZ |
| PAOK | | 1 - 1 | | Club Brugge |
| Villarreal | | 3 - 0 | | Dinamo Zagreb |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
