| Saturday, 25 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Sporting Gijón | | 23:00 | | Valencia |
| Sunday, 26 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Levante | | 01:00 | | Real Madrid |
| Athletic Bilbao | | 03:00 | | Barcelona |
| Racing Santander | | 22:00 | | Getafe |
| Deportivo de La Coruña | | 22:00 | | Almería |
| Espanyol | | 22:00 | | Osasuna |
| Mallorca | | 22:00 | | Real Sociedad |
| Monday, 27 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Hércules | | 00:00 | | Sevilla |
| Atlético Madrid | | 02:00 | | Real Zaragoza |
| Tuesday, 28 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Málaga | | 02:00 | | Villarreal |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
