| Wednesday, 24 Nov 2010 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Spartak Moskva | | 0 - 3 | | Olympique Marseille |
| Roma | | 3 - 2 | | Bayern München |
| Basel | | 1 - 0 | | CFR Cluj |
| Chelsea | | 2 - 1 | | Žilina |
| Ajax | | 0 - 4 | | Real Madrid |
| Auxerre | | 0 - 2 | | Milan |
| Partizan | | 0 - 3 | | Shakhtar Donetsk |
| Sporting Braga | | 2 - 0 | | Arsenal |
| Thursday, 25 Nov 2010 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Rubin Kazan | | 1 - 0 | | København |
| Internazionale | | 1 - 0 | | Twente |
| Tottenham Hotspur | | 3 - 0 | | Werder Bremen |
| Schalke 04 | | 3 - 0 | | Olympique Lyon |
| Hapoel Tel Aviv | | 3 - 0 | | Benfica |
| Rangers | | 0 - 1 | | Manchester United |
| Valencia | | 6 - 1 | | Bursaspor |
| Panathinaikos | | 0 - 3 | | Barcelona |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
