| DATE | HOME | TIME | AWAY | ||
| 17/8/10 | Aris |  | 23:00 |  | Austria Wien |
| 26/8/10 | Austria Wien | | 01:45 | | Aris |
| 17/8/10 | Besiktas |  | 23:00 |  | HJK |
| 26/8/10 | HJK | | 01:45 | | Besiktas |
| 19/8/10 | Sibir Novosibirsk |  | 19:00 |  | PSV |
| 27/8/10 | PSV | | 00:30 | | Sibir Novosibirsk |
| 19/8/10 | BATE |  | 23:00 |  | Marítimo |
| 26/8/10 | Marítimo | | 01:45 | | BATE |
| 19/8/10 | CSKA Moskva |  | 23:30 |  | Anorthosis |
| 24/8/10 | Anorthosis | | 23:00 | | CSKA Moskva |
| 19/8/10 | Bayer Leverkusen |  | 23:30 |  | Tavriya |
| 26/8/10 | Tavriya | | 01:45 | | Bayer Leverkusen |
| 19/8/10 | PSG |  | 23:30 |  | Maccabi Tel Aviv |
| 27/8/10 | Maccabi Tel Aviv | | 01:00 | | PSG |
| 19/8/10 | Rapid Wien |  | 23:45 |  | Aston Villa |
| 26/8/10 | Aston Villa | | 01:45 | | Rapid Wien |
| 19/8/10 | Slovan Bratislava |  | 23:45 |  | Stuttgart |
| 26/8/10 | Stuttgart | | 01:45 | | Slovan Bratislava |
| 20/8/10 | Debrecen |  | 00:00 |  | Lovech |
| 26/8/10 | Lovech | | 23:00 | | Debrecen |
| 20/8/10 | AIK |  | 00:00 |  | Levski Sofia |
| 26/8/10 | Levski Sofia | | 23:00 | | AIK |
| 20/8/10 | Dnipro Dnipropetrovsk |  | 00:00 |  | Lech Poznan |
| 26/8/10 | Lech Poznan | | 23:00 | | Dnipro Dnipropetrovsk |
| 20/8/10 | Omonia Nicosia |  | 00:00 |  | Metalist |
| 27/8/10 | Metalist | | 00:00 | | Omonia Nicosia |
| 20/8/10 | Vaslui |  | 00:00 |  | Lille |
| 27/8/10 | Lille | | 01:45 | | Vaslui |
| 20/8/10 | OB |  | 00:05 |  | Motherwell |
| 27/8/10 | Motherwell | | 01:45 | | OB |
| 20/8/10 | Feyenoord |  | 00:15 |  | Gent |
| 27/8/10 | Gent | | 01:00 | | Feyenoord |
| 20/8/10 | Steaua Bucureşti |  | 00:45 |  | Grasshopper |
| 26/8/10 | Grasshopper | | 01:00 | | Steaua Bucureşti |
| 20/8/10 | Galatasaray |  | 01:00 |  | Karpaty |
| 26/8/10 | Karpaty | | 23:00 | | Galatasaray |
| 20/8/10 | Hajduk Split |  | 01:30 |  | Unirea Urziceni |
| 26/8/10 | Unirea Urziceni | | 23:00 | | Hajduk Split |
| 20/8/10 | Palermo |  | 01:30 |  | Maribor |
| 26/8/10 | Maribor | | 23:00 | | Palermo |
| 20/8/10 | Lausanne Sports |  | 01:30 |  | Lokomotiv Moskva |
| 26/8/10 | Lokomotiv Moskva | | 23:00 | | Lausanne Sports |
| 20/8/10 | PAOK |  | 01:30 |  | Fenerbahce |
| 26/8/10 | Fenerbahce | | 23:00 | | PAOK |
| 20/8/10 | Club Brugge |  | 01:30 |  | Dinamo Minsk |
| 26/8/10 | Dinamo Minsk | | 23:00 | | Club Brugge |
| 20/8/10 | CSKA Sofia |  | 01:30 |  | Marítimo |
| 27/8/10 | Marítimo | | 01:35 | | CSKA Sofia |
| 20/8/10 | Genk |  | 01:30 |  | Porto |
| 27/8/10 | Porto | | 02:30 | | Genk |
| 20/8/10 | Celtic |  | 01:45 |  | Utrecht |
| 26/8/10 | Utrecht | | 23:00 | | Celtic |
| 20/8/10 | Timişoara |  | 01:45 |  | Manchester City |
| 26/8/10 | Manchester City | | 23:00 | | Timişoara |
| 20/8/10 | Liverpool |  | 01:45 |  | Trabzonspor |
| 27/8/10 | Trabzonspor | | 00:30 | | Liverpool |
| 20/8/10 | Napoli |  | 02:00 |  | Elfsborg |
| 26/8/10 | Elfsborg | | 23:00 | | Napoli |
| 20/8/10 | Getafe |  | 02:00 |  | APOEL |
| 26/8/10 | APOEL | | 01:45 | | Getafe |
| 20/8/10 | Dundee United |  | 02:00 |  | AEK |
| 26/8/10 | AEK | | 01:45 | | Dundee United |
| 20/8/10 | Györi ETO |  | 02:00 |  | Dinamo Zagreb |
| 26/8/10 | Dinamo Zagreb | | 23:00 | | Györi ETO |
| 20/8/10 | AZ |  | 02:00 |  | Aktobe |
| 26/8/10 | Aktobe | | 23:00 | | AZ |
| 20/8/10 | Sturm Graz |  | 02:05 |  | Juventus |
| 26/8/10 | Juventus | | 23:00 | | Sturm Graz |
| 20/8/10 | Borussia Dortmund |  | 02:05 |  | Qarabagh |
| 26/8/10 | Qarabagh | | 23:00 | | Borussia Dortmund |
| 20/8/10 | Sporting Lisbon |  | 02:30 |  | Brøndby |
| 26/8/10 | Brøndby | | 23:00 | | Sporting Lisbon |
| 20/8/10 | Villarreal |  | 03:00 |  | Dnepr Mogilev |
| 26/8/10 | Dnepr Mogilev | | 23:00 | | Villarreal |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
