| Wednesday, 15 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Twente | | 01:45 | | Internazionale |
| Werder Bremen | | 01:45 | | Tottenham Hotspur |
| Olympique Lyon | | 01:45 | | Schalke 04 |
| Benfica | | 01:45 | | Hapoel Tel Aviv |
| Manchester United | | 01:45 | | Rangers |
| Bursaspor | | 01:45 | | Valencia |
| Barcelona | | 01:45 | | Panathinaikos |
| København | | 01:45 | | Rubin Kazan |
| Thursday, 16 Sept 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Bayern München | | 01:45 | | Roma |
| CFR Cluj | | 01:45 | | Basel |
| Olympique Marseille | | 01:45 | | Spartak Moskva |
| Žilina | | 01:45 | | Chelsea |
| Milan | | 01:45 | | Auxerre |
| Real Madrid | | 01:45 | | Ajax |
| Arsenal | | 01:45 | | Sporting Braga |
| Shakhtar Donetsk | | 01:45 | | Partizan |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
