| Wednesday, 24 Nov 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Spartak Moskva | | 00:30 | | Olympique Marseille |
| Roma | | 02:45 | | Bayern München |
| Basel | | 02:45 | | CFR Cluj |
| Chelsea | | 02:45 | | Žilina |
| Ajax | | 02:45 | | Real Madrid |
| Auxerre | | 02:45 | | Milan |
| Partizan | | 02:45 | | Shakhtar Donetsk |
| Sporting Braga | | 02:45 | | Arsenal |
| Thursday, 25 Nov 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Rubin Kazan | | 00:30 | | København |
| Internazionale | | 02:45 | | Twente |
| Tottenham Hotspur | | 02:45 | | Werder Bremen |
| Schalke 04 | | 02:45 | | Olympique Lyon |
| Hapoel Tel Aviv | | 02:45 | | Benfica |
| Rangers | | 02:45 | | Manchester United |
| Valencia | | 02:45 | | Bursaspor |
| Panathinaikos | | 02:45 | | Barcelona |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
