| Friday, 22 Oct 2010 | ||||
| HOME TEAM | SCORE | AWAY TEAM | ||
| Besiktas |  | 1 - 3 |  | Porto |
| CSKA Sofia |  | 0 - 2 |  | Rapid Wien |
| Napoli |  | 0 - 0 |  | Liverpool |
| Utrecht |  | 1 - 1 |  | Steaua Bucureşti |
| Karpaty |  | 0 - 1 |  | Sevilla |
| Borussia Dortmund |  | 1 - 1 |  | PSG |
| Debrecen |  | 1 - 2 |  | PSV |
| Metalist |  | 2 - 1 |  | Sampdoria |
| Stuttgart |  | 1 - 0 |  | Getafe |
| Young Boys |  | 4 - 2 |  | OB |
| Anderlecht |  | 3 - 0 |  | AEK |
| Zenit St. Petersburg |  | 2 - 0 |  | Hajduk Split |
| Lille |  | 1 - 0 |  | Levski Sofia |
| Sporting Lisbon |  | 5 - 1 |  | Gent |
| Aris |  | 0 - 0 |  | Bayer Leverkusen |
| Atlético Madrid |  | 3 - 0 |  | Rosenborg |
| Salzburg |  | 1 - 1 |  | Juventus |
| Manchester City |  | 3 - 1 |  | Lech Poznan |
| Sparta Praha |  | 3 - 3 |  | Lausane Sports |
| Palermo |  | 0 - 3 |  | CSKA Moskva |
| AZ |  | 1 - 2 |  | Dynamo Kyiv |
| Sheriff |  | 0 - 1 |  | BATE |
| Dinamo Zagreb |  | 0 - 0 |  | Club Brugge |
| Villarreal |  | 1 - 0 |  | PAOK |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
