| Thursday, 2 Dec 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Sampdoria | | 01:00 | | PSV |
| Metalist | | 01:00 | | Debrecen |
| OB | | 01:00 | | Getafe |
| Hajduk Split | | 01:00 | | AEK |
| Zenit St. Petersburg | | 01:00 | | Anderlecht |
| Young Boys | | 01:30 | | Stuttgart |
| Gent | | 03:05 | | Levski Sofia |
| Sporting Lisbon | | 03:05 | | Lille |
| Rosenborg | | 03:05 | | Bayer Leverkusen |
| Atlético Madrid | | 03:05 | | Aris |
| Lech Poznan | | 03:05 | | Juventus |
| Manchester City | | 03:05 | | Salzburg |
| Friday, 3 Dec 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| CSKA Sofia | | 01:00 | | Besiktas |
| Utrecht | | 01:00 | | Napoli |
| Rapid Wien | | 01:00 | | Porto |
| Steaua Bucureşti | | 01:00 | | Liverpool |
| PSG | | 01:00 | | Sevilla |
| Borussia Dortmund | | 01:00 | | Karpaty |
| CSKA Moskva | | 01:00 | | Lausanne Sports |
| Palermo | | 03:05 | | Sparta Praha |
| BATE | | 03:05 | | Dynamo Kyiv |
| Sheriff | | 03:05 | | AZ |
| PAOK | | 03:05 | | Club Brugge |
| Villarreal | | 03:05 | | Dinamo Zagreb |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
