| DATE | HOME | TIME | AWAY | ||
| 17/8/10 | Zenit St. Petersburg |  | 23:30 |  | Auxerre |
| 26/8/10 | Auxerre | | 01:45 | | Zenit St. Petersburg |
| 18/8/10 | Rosenborg |  | 01:45 |  | København |
| 26/8/10 | København | | 01:45 | | Rosenborg |
| 18/8/10 | Sparta Praha |  | 01:45 |  | Žilina |
| 26/8/10 | Žilina | | 01:45 | | Sparta Praha |
| 18/8/10 | Young Boys |  | 01:45 |  | Tottenham Hotspur |
| 26/8/10 | Tottenham Hotspur | | 01:45 | | Young Boys |
| 18/8/10 | Dynamo Kyiv |  | 01:45 |  | Ajax |
| 26/8/10 | Ajax | | 01:45 | | Dynamo Kyiv |
| 19/8/10 | Salzburg |  | 01:45 |  | Hapoel Tel Aviv |
| 25/8/10 | Hapoel Tel Aviv | | 01:45 | | Salzburg |
| 19/8/10 | Basel |  | 01:45 |  | Sheriff |
| 25/8/10 | Sheriff | | 01:45 | | Basel |
| 19/8/10 | Partizan |  | 01:45 |  | Anderlecht |
| 25/8/10 | Anderlecht | | 01:45 | | Partizan |
| 19/8/10 | Sporting Braga |  | 01:45 |  | Sevilla |
| 25/8/10 | Sevilla | | 01:45 | | Sporting Braga |
| 19/8/10 | Werder Bremen |  | 01:45 |  | Sampdoria |
| 25/8/10 | Sampdoria | | 01:45 | | Werder Bremen |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
