| Wednesday,16 Feb 2011 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Aris | | 0 - 0 | | Manchester City |
| Thursday, 17 Feb 2011 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Rubin Kazan | | 0 - 2 | | Twente |
| Metalist | | 0 - 4 | | Bayer Leverkusen |
| Friday, 18 Feb 2011 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Napoli | | 0 - 0 | | Villarreal |
| Anderlecht | | 0 - 3 | | Ajax |
| Lech Poznan | | 1 - 0 | | Sporting Braga |
| Besiktas | | 1 - 4 | | Dynamo Kyiv |
| Benfica | | 2 - 1 | | Stuttgart |
| BATE | | 2 - 2 | | PSG |
| PAOK | | 0 - 1 | | CSKA Moskva |
| Sevilla | | 1 - 2 | | Porto |
| Rangers | | 1 - 1 | | Sporting Lisbon |
| Sparta Praha | | 0 - 0 | | Liverpool |
| Basel | | 2 - 3 | | Spartak Moskva |
| Young Boys | | 2 - 1 | | Zenit |
| Lille | | 2 - 2 | | PSV |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
