| Saturday, 23 Oct 2010 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Real Zaragoza | | 0 - 2 | | Barcelona |
| Sunday, 24 Oct 2010 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Real Madrid | | 6 - 1 | | Racing Santander |
| Valencia | | 1 - 2 | | Mallorca |
| Getafe | | 3 - 0 | | Sporting Gijón |
| Almería | | 1 - 1 | | Hércules |
| Osasuna | | 3 - 0 | | Málaga |
| Espanyol | | 2 - 1 | | Levante |
| Monday, 25 Oct 2010 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Sevilla | | 4 - 3 | | Athletic Bilbao |
| Villarreal | | 2 - 0 | | Atlético Madrid |
| Tuesday, 26 Oct 2010 |
| HOME TEAM | | SCORE | | AWAY TEAM |
| Real Sociedad | | 3 - 0 | | Deportivo de La Coruña |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
