| Tuesday, 19 Oct 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Spartak Moskva | | 23:30 | | Chelsea |
| Wednesday, 20 Oct 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Arsenal | | 01:45 | | Shakhtar Donetsk |
| Sporting Braga | | 01:45 | | Partizan |
| Real Madrid | | 01:45 | | Milan |
| Ajax | | 01:45 | | Auxerre |
| Olympique Marseille | | 01:45 | | Žilina |
| Bayern München | | 01:45 | | CFR Cluj |
| Roma | | 01:45 | | Basel |
| Thursday, 21 Oct 2010 |
| HOME TEAM | | TIME | | AWAY TEAM |
| Barcelona | | 01:45 | | København |
| Panathianikos | | 01:45 | | Rubin Kazan |
| Manchester United | | 01:45 | | Bursaspor |
| Rangers | | 01:45 | | Valencia |
| Olympique Lyon | | 01:45 | | Benfica |
| Schalke | | 01:45 | | Hapoel Tel Aviv |
| Twente | | 01:45 | | Werder Bremen |
| Internazionale | | 01:45 | | Tottenham Hotspur |
*(GMT+07:00) Bangkok, Hanoi, Jakarta
